A Versatile Probe For Chemoselective Capture And Analysis Of Carbonyl Compounds In Exhaled Breath

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We describe an aminooxy reagent for the capture of trace aldehyde and ketone volatile organic compounds (VOCs) in exhaled breath. The reagent, 4-(2-aminooxyethyl)-morpholin-4-ium chloride (AMAH), when coated onto micropillars within a silicon microreactor, chemoselectively and covalently retains carbonyl VOCs from exhaled breath. The AMAH–carbonyl adducts are then eluted from the microreactor with methanol and directly analyzed by Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry (MS), where the aminium ion of the reagent enhances the sensitivity for high mass accuracy

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High Sensitivity for Lung Cancer Detection by Analysis of Exhaled Carbonyl Compounds

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Objective: Several volatile carbonyl compounds in exhaled breath have been identified as cancer specific markers. The potential for these markers to serve as a screening test for lung cancer is reported. Methods: Patients with CT-detected intra-thoracic lesions and healthy controls were enrolled from 2011 onwards. One liter of breath was collected from a single exhalation. The contents were evacuated over a silicon microchip, captured by oximation reaction, and analyzed by mass spectrometry.

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Breath Carbonyl Compounds As Biomarkers Of Lung Cancer

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Objective: Lung cancer dysregulations impart oxidative stress which results in important metabolic products in the form of volatile organic compounds (VOCs) in exhaled breath. The objective of this work is to use statistical classification models to determine specific carbonyl VOCs in exhaled breath as biomarkers for detection of lung cancer.

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A Microfabricated Preconcentration Device For Breath Analysis

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Breath analysis promises to be a noninvasive method for diagnosis of lung cancer in its early stages. Certain ketones and aldehydes in exhaled breath have been identified as indicators of lung cancer. We report a preconcentration device or preconcentrator with thousands of micropillars fabricated from a silicon wafer that have been engineered to selectively trap trace gaseous ketones and aldehydes in exhaled breath.

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Quantitative Analysis Of Exhaled Carbonyl Compounds Distinguishes Benign From Malignant Pulmonary Disease

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Objectives: The analysis of exhaled breath is a promising noninvasive tool for the diagnosis of lung cancer, but its clinical relevance has yet to be established.We report the analysis of exhaled volatile carbonyl compounds for the identification of specific carbonyl cancer markers to differentiate benign pulmonary disease from early-stage lung cancer and to compare its diagnostic accuracy with positron emission tomography (PET) scans.

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Preconcentration And Analysis Af Trace Volatile Carbonyl Compounds

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Objectives: The analysis of exhaled breath is a promising noninvasive tool for the diagnosis of lung cancer, but its clinical relevance has yet to be established.We report the analysis of exhaled volatile carbonyl compounds for the identification of specific carbonyl cancer markers to differentiate benign pulmonary disease from early-stage lung cancer and to compare its diagnostic accuracy with positron emission tomography (PET) scans.

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